The unique activity of forskolin as a non adrenergic stimulator of Adenylate cyclase attracted attention of medical researchers to start their work using forskolin in their research.
The primary mode of action of forskolin is by increasing the cellular concentrations of cyclic AMP (cAMP) and cAMP mediated functions, via the activation of the enzyme Adenylate cyclase1.
Adenylate cyclase is the enzyme involved in the production of Cyclic Adenosine Monophosphate (cAMP), a very important molecule, known as “second messenger”
referring to its broad range of activities in the body’s life sustaining reactions. Stimulation of adenylate cyclase is thought to be the mechanism by which
forskolin relaxes a variety of smooth muscles2.
The biochemical mechanism of maintaining or increasing lean body mass is related to the availability of cyclic AMP.
By facilitating hormonal action, cyclic AMP may regulate the body's thermogenic response to food, increase the
body's basic metabolic rate, and increase utilization of body fat (since thermogenesis is preferentially fueled by fatty acids
derived from body fat and/or food).
Research carried out over the last few decades has revealed the multi-faceted pharmacological effects of Forskolin.
Most of these effects have been linked to the role of forskolin as an activator of Adenylate cyclase.
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